Blog and News

  • New publication featuring orexin A, a neuropeptide that is important for pleiotropic functions in the nervous and immune systems::

https://www.sciencedirect.com/science/article/pii/S0301462223000583

  • New publication in Scientific Reports on enhancing the anticancer activity of host defense peptides through copper binding:

https://www.nature.com/articles/s41598-021-91670-w

https://phys.org/news/2021-10-copper-binding-peptides-fish-anticancer-agents.html

https://www.wtkr.com/news/health/william-mary-researchers-say-compound-in-fish-could-be-key-to-defeating-cancer

https://www.labroots.com/trending/cell-and-molecular-biology/21444/anti-cancer-copper-binding-compounds-found-fish

  • Lab publishes article on role of aromatic residues in stabilizing metal binding within membrane-binding peptide:

https://doi.org/10.1021/acs.jpclett.1c00636

  • Cotten gives invited talk at 61st ENC, March 2020:

https://www.enc-conference.org/ProgramAbstracts/InvitedSpeakers/tabid/191/Default.aspx

  • JBC article is published showing that piscidins leverage membrane heterogeneity for their membrane activity:

https://www.jbc.org/content/294/49/18557

  • JACS cover article on the role of histidine for directionality of membrane insertion:

https://pubs.acs.org/toc/jacsat/141/28

  • Daily Press article

https://www.dailypress.com/2018/12/30/study-shows-rockfish-peptides-could-make-great-rx-for-human-ills/

  • ChemPhysChem article publication on structural studies by NMR of metallated piscidin:

https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201800855

  • J. Biol. Chem publication in September 2018:

“Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin”

http://www.jbc.org/content/early/2018/08/28/jbc.RA118.001904.abstract

  • FEBS J. publication in November 2017:

“Nuclease activity gives an edge to host-defense peptide piscidin 3 over piscidin 1, rendering it more effective against persisters and biofilms”

http://onlinelibrary.wiley.com/doi/10.1111/febs.14263/full

Highlights of the FEBS J. publication: “Fishing for new antibiotics” on Phys.org

https://phys.org/news/2017-10-fishing-antibiotics.html